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I knelt beside him and felt for a pulse. Faster than two a second, and pounding.
The fastest way to derail convulsions is a shot of nano programmed to hit the brain’s limbic system and decouple the spasmodic neuronic output, a nanoneural suppression, or NNS. That’s the way we treat epileptic seizures. The trouble was, this wasn’t necessarily epilepsy, and messing with the brain, outside of relatively straightforward pain control, is not business as usual for a Corpsman.
I opened an in-head CDF channel. “Dr. Francis? I need you up here. B Deck, berthing compartment eleven two.”
“Already on my way, Carlyle. What do we have?”
“Twenty-year-old male in convulsions. Elevated heart and BP.” I hesitated. “He was at sick call this morning with symptoms of the flu.”
“Go ahead and initiate an NNS.”
“Aye, aye, sir.”
I pulled a spray injector from my kit and clicked in a plastic capsule of gray liquid, held the tip against Howell’s carotid, and fired it into his bloodstream. Elsewhere in my kit was an N-prog, a handheld device that used magnetic induction to program nanobots after they were inside the body. I switched it on and glanced at the screen.
What the hell? The device was picking up easily twice the dosage of ’bots, and they were already running a program. Not only that, they were recruiting the new ’bots, passing on their programming as the new ’bots flooded into Howell’s brain. On-screen, I could see a graphic representation of the nanotech war going on inside his brain—a haze of red dots and gray dots, with more and more of the gray switching to red as I watched.
And the seizures became more violent, horrifically so. Howell’s back arched so sharply, his hips thrust forward, I was afraid his spine was going to snap. With each thrust, he gave another bellow. The muscles were standing out on his neck like steel bars, his mouth wide open, and blood was streaming from his nose. This was not good. If I didn’t get the convulsions under control soon, he would have a massive stroke or a heart attack on the spot.
I punched in my code, then entered Program 9, holding the N-prog close to the side of his head. The remaining gray dots turned green and, slowly, slowly, the red dots began switching to green as well.
“C’mon! C’mon!” I breathed, watching the slow change in colors. Green ’bots meant they’d accepted the new program, which would guide them through the brain tissues to the limbic system and to the motor-control areas and the cerebellum, where they should start damping out the neural storm that was wracking Howell’s brain.
Damn it. I wanted to call it epilepsy, but it wasn’t, though it showed some of the same signs and symptoms. It looked as though Howell’s limbic system had just started firing off high-energy signals. The red nano was behind it, I suspected. Somehow, they appeared to be programmed to enter the limbic system and stimulate the neuron firings that had resulted in Howell’s bizarre seizure. I could see that the red ’bots were clustered in several particular spots deep within Howell’s brain—a region called the ventral tegemental area, or VTA, and another called the substantia nigra. I didn’t know what that meant; Corpsmen are given basic familiarization in brain anatomy, of course, but detailed brain chemistry is definitely a subject for specialists and expert AIs.
I needed to know what was going on in there chemically. I tapped out a new program code, setting it to affect just ten percent of the nanobots I’d just put into Howell’s brain.
Interstitial fluid—the liquid that fills the spaces between the body’s cells—is a witches’ brew of water filled with salts, amino acids and peptides, sugars, fatty acids, coenzymes, hormones, neurotransmitters, and waste products dumped by the cells. It’s not the same as blood or blood plasma; red cells, platelets, and plasma proteins can’t pass through the capillary walls, though certain kinds of white blood cells can squeeze through to fight infection. The exact composition depends on where in the body you’re measuring, but with nerve cells the interstitial fluid is where the chemical exchange takes place across a synapse, the gap between one nerve cell and another. I was telling the ’bots to begin directly sampling the mix of complex molecules floating among Howell’s neurons.
The answer came back as a long scrolling list of substances, but one formula by far outweighed all of the others: C
H
NO
. I had to look it up in my in-head reference library, and when I saw what it was I could have kicked myself.
Dopamine.
About then is when Dr. Francis arrived. “Make a hole!” one of the Marines barked, and the cluster of people around me and Howell scattered apart. I handed him my N-prog with the formula still showing on the screen.
“Shit,” was all he said when he read it.
Using my N-prog, he took over the programming of the nanobots, checking the progress of Program 9 first. There were definitely fewer of the red specks now, and a lot more of the green. In addition, some had switched over to orange, the ’bots engaged in sampling Howell’s cranial interstitial fluid.
The nanoneural suppression routine appeared to be working, once the green ’bots got a substantial upper hand over the red ’bots in numbers. Howell’s back was still arched, the muscular contractions were continuing, but they were decidedly weaker now, and expressing themselves as a long, steady quiver rather than the violent thrusting motions of a moment ago.
Dr. Francis was tapping in a new program code. “Neuroleptic intervention at the D2 receptors,” he told me. “It blocks dopamine.”
The ’bots clustered in Howell’s VTA were almost all green now, and the effect was spreading out through the motor region of his cerebral cortex and his cerebellum as well. The motor cortex is what plans and controls voluntary motor functions of the body—muscular movements, in other words. The cerebellum is the part of the brain at the very back and bottom of the organ that regulates the body’s muscular movements. It doesn’t initiate them, but it does help control them to fine-tune motor activity, timing, and coordination. Those parts of Howell’s brain had been completely out of control, causing all of his muscles to lock up in an involuntary, spasmodic seizure. As the motor-control regions relaxed, Howell’s body relaxed. His face sagged out of its rigid, openmouthed grimace, his fists unclenched, his spine eased into a more normal posture. Howell was panting now, but his eyes blinked, and he seemed to be aware of us now.
His eyes looked unusually dark.
“What happened, Private?” I asked him.
“I … dunno, Doc. I was just relaxing in my bunk, and wham! I don’t know what hit me.”
“How long have you been doing onan?” Dr. Francis asked, his voice level and matter-of-fact.
“Onan? I … ah … don’t know what you mean, sir.”
“Sure you do, son,” Francis replied. “You have enough dopamine in your system to trigger a hundred sexual orgasms. You were onanning and o-looping. Feels better than the real thing, eh?”
Of course, when the doctor said that it was all obvious. “Shit!” I said. “He’s addicted?”
“That’s one word for it,” Francis replied, studying the N-prog’s screen. “Ah. The dopamine levels are coming down. I think we’ve broken the monkey’s back.”
I only half heard him. I was in-head, opening up my personal library and downloading the entry on onan. I’d known this stuff, once, but it wasn’t the sort of thing you worked with every day, and I never thought about it.
Download, Ship’s Medical Library
“Onan,” “onanning”
From “O-nano,” a contraction for “orgasmic nano.”
Slang term referring to the use of programmed medical nano to affect the pleasure center of the brain directly in order to generate sexual orgasm. Nanobot programs can be directed to effect the release of massive amounts of dopamine in the brain, or to trigger spasmodic muscle contractions, or, more usually, both.
The term “onan” is a play on Onan, the name of a minor character in the Book of Genesis (q.v.).
Cute. I remembered it now. In the Jewish-Christian Bible, there’s the story of Onan, who dumped his semen on the floor rather than impregnate his dead brother’s wife, which apparently pissed Yahweh off so badly he struck Onan dead on the spot. For years, onanism was a synonym for masturbation, and carried with it the idea that God was going to throw a lightning bolt at you if you jacked or jilled off. What generation upon generation of relaxed but guilt-ridden teenagers afterward managed to miss was that the sin of Onan lay in his disobeying God—according to Jewish law he was supposed to father a son by his sister-in-law to preserve his brother’s bloodline. It had nothing to do with masturbation.
Today, of course, the so-called sin of Onan is long forgotten, but orgasmic nanotechnics are very much with us. You can program one-micron nanobots, you see, to go into the brain’s limbic system and trigger the neurochemical processes that result in sexual orgasm. Sometimes we do this deliberately, as a treatment for certain types of sexual dysfunction, but there’s also a thriving underground business in providing doses of sex-programmed nanobots that can go into the brain and stimulate an orgasm, and then do it again, and again, and again …
That part, programming the ’bots to give you one orgasm after another every second or two is known as o-looping, and it can be addictive—very highly so.
Not to mention dangerous.
It turns out that drugs like cocaine and amphetamines either trigger or mimic the release of dopamine, and they affect the same areas of the limbic system that light up during an orgasm—the VTA and the brain’s mesolimbic reward pathway. In fact, a brain scan taken during an orgasm shows a process ninety-five percent identical to a heroin rush. Drugs and orgasms hit the same part of the brain, and that’s what makes cocaine and other such drugs addictive.
That doesn’t mean sex is bad, of course. It’s natural, normal, and healthy. But deliberately and artificially overstimulating dopamine production can lead to an addiction requiring higher and higher dopamine levels to get the same kick as the dopamine receptors begin closing down. And the program Howell had been running, evidently, had involved overstimulation of the parts of the brain responsible for muscular contraction as well. It was a way to boost the orgasmic feeling, yeah, but it could have killed him too.
The curious thing is that dopamine doesn’t give you the feel-good kick itself. Dopamine is the hormone that makes you want—it’s the craving.
But it’s the flood of dopamine that makes a heroin addict want another hit.
And it drives our orgasmic cravings as well.
“I take it,” Dr. Francis said quietly, “that you didn’t check him for dope levels at sick call this morning.”
“No, sir.”
“Why not?”
“I didn’t see any need. It looked like a cold or maybe flu.”
“Did you look at his eyes?”
I glanced down at Howell’s face. In the harsh light from the overhead, his pupils were so widely dilated that his eyes looked unusually dark.
“No, sir. He was complaining that the light hurt his eyes.”
“Uh-huh. Addicts will do that, to hide their pupils. They’ll look everywhere except right at you. Did you notice that he happened to have a monster hard-on?”
“No, sir.” The long bulge at the crotch of Howell’s skinsuit was fading, but still hard to miss. Marines shipboard tend to wear nano-grown skinsuits like work utilities, since they’re disposable and Marines wear them under combat armor anyway. The things are pretty revealing, which doesn’t matter since the old American nudity taboos have pretty much gone the way of the dinosaur, and service men and women sleep and shower communally anyway.
His erection was painfully evident, even now. But, no, I hadn’t noticed. There’d been other things on my mind at the time besides Howell’s crotch.
“Get a stretcher team and get him down to sick bay,” Francis told me. “He should be okay, but we’ll need to follow up the neuroleptics, and he’ll need a complete scan to check for internal injury, electrolyte balance, and lactic-acid buildup. Once things are back in balance, we’ll do a flush on the ’bots, get them out of there.” He pinched Howell’s arm as I had earlier. “Dehydrated. When you get him to sick bay, put him on IV fluids. Think you can manage that?”
“Yes, sir.”
“Hey, Doc?” Howell said. His voice was weak, and it trembled a bit. “Am I in trouble?”
“You’re on report,” Dr. Francis told him, “if that’s what you mean. Misuse of nanomedical technology is damned dangerous. I imagine Captain Reichert is going to have words with you about damaging government property.”
“What government property?”
“You. Your body.”
I’d already used my in-head com link to call for a stretcher team. In the meantime, I helped Howell get up and into his bunk. The other Marines began dispersing, a little reluctantly. It had been quite a show.
And by the time we had him in sick bay, with an IV dripping Ringer’s lactate into his arm, we were sliding into Earth orbit, the tugs on their way out to haul us in and dock us with the Supra-Cayambe Starport Facility.
Later that afternoon, Lieutenant Commander Francis called me into his office. “Have a seat, Carlyle.”
“Yes, sir.”
“You missed some important shit with Howell, son.” He didn’t sound angry. He sounded disappointed, which was worse.
“I know that, sir.”
“Why?”
“I … no excuse, sir.”
“On board ship, our patients tend to be young and very, very healthy. Oh, you’ll get the occasional case of appendicitis or a sprained ankle or even a cold, but when one comes to you with vague symptoms like that, you need to consider the possibility that he did something to himself.
“Because our patients on board ship also tend to be very bored. They tend to be good at figuring out ways to subvert the system and apply technology to alleviate that boredom.”
I thought about Doobie and his lab-brewed hooch. “Yes, sir.”
“That’s especially true if he comes to you asking for a dose of nanomeds. Every technology can be misused in one way or another. It’s ridiculously easy for these kids to go on liberty and buy a handheld unit that can program ’bots to do damned near anything, just about. Onans are probably the most common. But they have them for programming a heroin rush, which is pretty much the same thing. Or cocaine. Or even, believe it or not, the feeling of contentment after a good meal.”
“Is that addictive, Doctor?”
“Can be. I saw one young enlisted woman a few years ago who was anorexic. She used an N-prog to feel full, like she’d just had a good meal, and stopped eating. We almost didn’t save her.”
“That’s just nuts, sir.”
“No, it’s just human. Humans do stupid things, or humans get screwed up in the head and that makes them to do stupid things.”
“Yes, sir.” I hesitated. “But—”
“But what?”
“I’m curious about Howell, sir. If he programmed the ’bots in his system to stimulate dopamine production … that’s just the craving, isn’t it? How did that cause the muscle spasms? And why did he go into convulsions? I didn’t give him any nanomeds this morning. Just aspirin.”
“Hm.” For a moment, he got a faraway look in his eyes, as though he were listening to something. “Do you know the term synaptic plasticity?”
“No, sir. I know what a synapse is.”
“The gap between one nerve cell and the next, yes. Synaptic plasticity is the tendency of the connection across the synapses to change in strength, either with use or with disuse. Among other things, it means the ability to change the quantity of neurotransmitters released into a synapse, and how well the next neuron in the chain responds to them. It’s an important factor in learning.”
“Okay …”
“Aspirin can affect synaptic plasticity. One of aspirin’s metabolic by-products, salicylate, acts on the NMDA receptors in cells, and that affects the flow of calcium ions across a neural synapse.”
At this point, Dr. Francis was way over my head. I had absolutely no idea what an NMDA receptor might be.
He must have sensed my confusion. “Don’t worry about it. My guess is Howell had a resident population of nanobots in his brain, programmed to give him an orgasm anytime he wanted, okay?”
I nodded.
“Dopamine is a neurotransmitter. One of the characteristics of neurotransmitters is you get a weakening effect each time you fire them.” He waved his hand in a descending series of peaks to illustrate. “You get this much of a jolt, then a little less, and a little less, like this. In an addiction, you need to boost the dosage of your drug of choice to get the same bang for your buck, right?”
“Yes, sir.” This was more familiar territory.
“Well, the same thing happens with dopamine. He might even have been going into withdrawal. Dopamine affects the same parts of the limbic system that heroin and cocaine hits.”
“Yeah. Headache. Runny nose. General aches and pains.”
“Symptoms like the flu,” Francis said. “Exactly. So he came to you to get you to prescribe a shot of nano, with the idea that more is better. He could reprogram what you gave him … or it looks like the nanobots he already had were set to reprogram anything new. You gave him aspirin instead. Maybe he took them back to the berthing compartment and downed them all, just hoping something would happen. The full chem workup we pulled on him this afternoon showed elevated salicylate levels.
“He might have boosted the programming on his nanobots, too. Upped the power, and maybe set them to deliberately give him an hour of multiple orgasms. We’ll know that if we find his N-prog in his locker. One way or another, though, the aspirin increased the efficiency of neurotransmitter uptake—specifically of dopamine. It also might have increased the triggering receptivity of his muscles. Aspirin is a decent muscle relaxant.”
The realization of what he was saying had just hit me, bam. “You’re saying I … I poisoned Howell, sir. I gave him that aspirin, and that’s what triggered the convulsions.”
“Not at all. I’m saying that when you’re working with these people, you need to be suspicious. Paranoid, even. What are they trying to put over on you?” He scowled. “It’s ridiculous. Most of them have fuck buddies in the squad bay, for God’s sake. Virtual reality feeds from the ship’s library let them have sex in their heads with all the hottest erotic stars on the Net. And still they screw with illegal nano programmers, trying to get a bigger kick, or they o-loop them to get a whole lot of them in a row.
